Center for Proteomics and Bioinformatics

Modern applications of proteomics techniques followed by bioinformatics analyses put the Center for Proteomics and Bioinformatics at the forefront of translational research in the Case Western Reserve University School of Medicine.

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News and Announcements

School of Medicine researchers discover new target for personalized cancer therapy

A common cancer pathway causing tumor growth is being targeted by a number of new cancer drugs and shows promising results. A team of researchers at Case Western Reserve University School of Medicine has developed a novel method to disrupt this growth-signaling pathway, with findings that suggest a new treatment for breast, colon, melanoma and other cancers. Learn more>>

Time.com discusses proteomics and Big Data in Blood Work.

Vishal Patel

Dr. Vishal Patel visits the Bioinformatics Institute in Bangalore India.

Learn more>>






Structural Biology and Biophysics Training Program

Structural Biology and Biophysics Training Program (SBB_TP)

The Structural Biology and Biophysics Training Program emphasizes quantitative methods and equips students to study cell and protein structure and function using state-of-the-art instrumentation and computing. The Department hosts outstanding research programs in the areas of structural biology and cellular ion channels and transporters.

Qualified students receive full tuition waiver, a stipend, and health benefits during the full duration of their studies.

Students can enter this training program by admission to the Interdepartmental Structural Biology and Biophysics Training Program (http://sbb-tp.case.edu).

Research Highlights

Cross-talk between the ligand- and DNA-binding domains of estrogen receptor

Cross-talk between the ligand- and DNA-binding domains of estrogen receptor

Estrogen receptor alpha (ER.) is a hormone-responsive transcription factor that contains several discrete functional domains, including a ligand-binding domain (LBD) and a DNA-binding domain (DBD). Despite a wealth of knowledge about the behaviors of individual domains, the molecular mechanisms of cross-talk between LBD and DBD during signal transduction from hormone to DNA-binding of ERα remain elusive. >>


Endogenous protein S-nitrosylation in E. coli

Endogenous protein S-nitrosylation in E. coli: regulation by OxyR

Endogenous S-nitrosylation of proteins, a principal mechanism of cellular signaling in eukaryotes, has not been observed in microbes. We report that protein S-nitrosylation is an obligate concomitant of anaerobic respiration on nitrate in E. coli. Endogenous S-nitrosylation during anaerobic respiration is controlled by the transcription factor OxyR, >>

Joint adaptive mean-variance regularization and variance stabilization of high dimensional data

Joint adaptive mean-variance regularization and variance stabilization of high dimensional data

The paper addresses a common problem in the analysis of high-dimensional high-throughput "omics" data, which is parameter estimation across multiple variables in a set of data where the number of variables is much larger than the sample size.

Molecular and Cellular Proteomics Cover October 2012

DNA and Chromatin Modification Networks Distinguish Stem Cell Pluripotent Ground States

Pluripotent stem cells are capable of differentiating into all cell types of the body and therefore hold tremendous promise for regenerative medicine. Despite their widespread use in laboratories across the world, a detailed understanding of the molecular mechanisms that regulate the pluripotent state is currently lacking. >>

Seminars and Workshops

  • 4/24/2014 - 12:00pm - 1:00pm BRB 932 - Dr. Matthias Buck will be presenting "Structure And Dynamics Of The Plexin Transmembrane Receptor Bound To Gtpases And To The Lipid Bilayer."
  • 5/1/2014 - 12:00pm - 1:00pm BRB 932 - Dr. Parminder Kaur will be presenting "Uncovering biomolecular structure at single residue resolution using mass spectrometry based covalent labeling"

Research Highlights