Modern applications of proteomics techniques followed by bioinformatics analyses put the Center for Proteomics and Bioinformatics at the forefront of translational research in the Case Western Reserve University School of Medicine.
School of Medicine researchers discover new target for personalized cancer therapy
A common cancer pathway causing tumor growth is being targeted by a number of new cancer drugs and shows promising results. A team of researchers at Case Western Reserve University School of Medicine has developed a novel method to disrupt this growth-signaling pathway, with findings that suggest a new treatment for breast, colon, melanoma and other cancers. Learn more>>
Dr. Vishal Patel visits the Bioinformatics Institute in Bangalore India.
Structural Biology and Biophysics Training Program (SBB_TP)
The Structural Biology and Biophysics Training Program emphasizes quantitative methods and equips students to study cell and protein structure and function using state-of-the-art instrumentation and computing. The Department hosts outstanding research programs in the areas of structural biology and cellular ion channels and transporters.
Qualified students receive full tuition waiver, a stipend, and health benefits during the full duration of their studies.
Students can enter this training program by admission to the Interdepartmental Structural Biology and Biophysics Training Program (http://sbb-tp.case.edu).
Cross-talk between the ligand- and DNA-binding domains of estrogen receptor
Estrogen receptor alpha (ER.) is a hormone-responsive transcription factor that contains several discrete functional domains, including a ligand-binding domain (LBD) and a DNA-binding domain (DBD). Despite a wealth of knowledge about the behaviors of individual domains, the molecular mechanisms of cross-talk between LBD and DBD during signal transduction from hormone to DNA-binding of ERα remain elusive. >>
Endogenous protein S-nitrosylation in E. coli: regulation by OxyR
Endogenous S-nitrosylation of proteins, a principal mechanism of cellular signaling in eukaryotes, has not been observed in microbes. We report that protein S-nitrosylation is an obligate concomitant of anaerobic respiration on nitrate in E. coli. Endogenous S-nitrosylation during anaerobic respiration is controlled by the transcription factor OxyR, >>
Joint adaptive mean-variance regularization and variance stabilization of high dimensional data
The paper addresses a common problem in the analysis of high-dimensional high-throughput "omics" data, which is parameter estimation across multiple variables in a set of data where the number of variables is much larger than the sample size.
DNA and Chromatin Modification Networks Distinguish Stem Cell Pluripotent Ground States
Pluripotent stem cells are capable of differentiating into all cell types of the body and therefore hold tremendous promise for regenerative medicine. Despite their widespread use in laboratories across the world, a detailed understanding of the molecular mechanisms that regulate the pluripotent state is currently lacking. >>