Proteomics Research in Systems Medicine (PRISM) Summer Undergraduate Research Program

Purpose: To promote and support undergraduates' participation in biomedical research.

Eligibility: All undergraduate students at Case Western Reserve University who are continuing as undergraduates in fall 2013 are eligible to apply for PRISM summer funding. Students who are awarded a summer research experience cannot enroll in summer classes. Students are expected to conduct research for 40 hours per week for 10 weeks. Students will be awarded a stipend of $3500 plus $1500 toward CWRU guest housing.

Program Dates: May 28, 2013 - August 2, 2013

Applicants must choose from 1 of 2 available projects in their application.

Project 1: Structural studies in visual signalling networks
Mentor: David Lodowski, PhD. Assistant Professor, Center for Proteomics and Bioinformatics

The goal of this summer research project is to assist in elucidating the structures of the protein complexes that underlie mammalian visual signalling. By employing a combination of X-ray crystallography, electron microscopy and mass spectrometry we are able to assemble three dimensional models of protein complexes involved in vision.

The ultimate goal of this project is to gain a more complete understanding of the visual signalling network by combining these structural models with biochemical and biophysical studies. The student should have interest in or experience with structural biology techniques or mass spectrometry. A selected student will assist in the structure determination of protein complexes by EM and X-ray crystallography. Training in laboratory safety will be provided.

Project 2: Structure Prediction of Protein-Protein Interactions
Mentor: Sichun Yang, PhD. Assistant Professor, Center for Proteomics and Bioinformatics

Predicting protein-protein interactions has a central role in many critical biological processes. Students will be actively involved in using a novel computational algorithm developed in our lab to predict the structures of protein-protein complexes.

The outcomes of this project will be directly integrated into a worldwide competition (CAPRI) for structure prediction on protein-protein interactions. By participating in this project, students will develop a valuable skill-set of using large-scale computer simulations via the CWRU High Performance Computing Cluster (HPCC) facility for biomedical research.

Programming experience in any language/script is a plus.

The deadline to submit a completed application to Joan Schenkel, 10900 Euclid Ave, BRB 933, Cleveland, OH, 44106-4988 or attach as one pdf to March 1, 2013. Your resume and transcript are required to complete your application.

Selection Criteria:
Applications will be reviewed to confirm that the applicant meets the eligibility criteria. The selection committee will evaluate applications based upon application materials and research interests. Selected finalists will be asked to come to the Center for Proteomics and Bioinformatics for an interview.

Questions? Please contact Joan Schenkel,

Download the application form.