The Center for Proteomics and Bioinformatics features:
The Case Center for Proteomics and Bioinformatics was created, in part, to strengthen Cleveland's presence in modern proteomics and bioinformatics research to make the region a leader in the field. The vision for the Center has been shaped over the past several years by the leadership of the Center.s Director, Mark Chance, Ph.D, with over $60 million in grants awarded to the Center and its collaborators since its inception in February 2006. One of the primary goals of the CPB is to develop an infrastructure of sophisticated equipment that facilitates and maximizes shared equipment usage, as well as to offer a wide array of proteomics and bioinformatics services including 2D gel, mass spectrometry, protein expression/interactions, systems biology, and biostatistical analyses.
Proteomics entails the in depth structural analysis of individual proteins in human and animal cells. In studying proteins and their changes, bioinformatics enables researchers to take an integrated -omics approach for discovering networks involved in human disease. The School of Medicine has established the Center for Proteomics and Bioinformatics to perform research to better understand the genetic and environmental bases of disease as well as provide new technologies to diagnose diseases such as cancer, heart disease, and diabetes.
New technologies in mass spectrometry are also allowing protein expression, localization, structure, post-translational modifications, and interactions to be studied in increasing detail and on a genome wide scale. The Center is also developing and applying state-of-the-art-structural proteomics technologies to understand the function and interactions of macromolecular complexes.
The mission of the Division of Proteomics and Genomics is to support research in protein and gene expression analysis, protein and gene modifications, and protein interactions in a wide variety of biological contexts. The division also develops new tools in Proteomics and Genomics research. This includes multiple Proteomics Cores to support these activities.
The mission of the Division of Bioinformatics is to support interdisciplinary research and training in many areas of bioinformatics including analysis of DNA and protein sequences, protein interaction networks, linkage and association studies for simple and complex traits, and gene and protein expression profiles. This includes a Bioinformatics Core that provides research support for these activities.
The mission of the Division of Macromolecular Structure is to support interdisciplinary research in new methods of structure determination, the combination of computational and experimental structural biology approaches, and developing and maintaining infrastructure for macromolecular structure determination. The Division will work closely and coordinate their activities with faculty and Departments in the University who use structural information to understand function as well as other Centers that provide leadership in Structural Biology and Biophysics.
The Center for Proteomics and Bioinformatics is located on the 9th floor of the Biomedical Research Building in the Case Western Reserve University School of Medicine. Visitor parking is available in the Veale Parking Garage located at the intersection of Adelbert Rd. and Cummington Rd. (a.k.a. Circle Dr.). The BRB is an 11-story, red-brick building with a clock at the top of it, and can be accessed from Adelbert Rd. (The BRB is located just to the right of Rainbow Babies & Children's hospital.)
There will be a security desk on your right as you enter the BRB-School of Medicine. Please tell them you're here to visit the Center for Proteomics and Bioinformatics on the 9th floor and they will give you access to the elevators.