Center for Proteomics and Bioinformatics:
Department of Genetics:
|1996||Ph.D, Plant molecular genetics, University of Oxford, UK|
|1997-1999||Post-doctoral fellow, Carnegie Institution of Washington/Stanford University, USA Post-doctoral fellow, CNRS, Marseilles, France|
|1999-2001||Post-doctoral fellow, Carnegie Institution of Washington/Stanford University, USA|
|2001-2003||Senior bioinformatics scientist, Incyte Genomics, Palo Alto, USA|
|2003-2005||Group leader, Bioinformatics, MDS Proteomics, Toronto, Canada|
|2006||Co-founder, Infochromics, Toronto, Canada|
1. Development of a combined proteomics/computational approach to mapping protein-protein interaction networks and understanding how perturbations to those networks impact cellular function.
Over the last few years, several studies have generated (albeit partial and noisy) snapshots of protein-protein interaction networks in model organisms. These datasets have been analyzed in many ways and have provided insights into protein function and network topology. Our interest is to focus on specific sub-networks and to understand how cellular perturbations (mutation, drug, allelic variation etc) impact network function
2. Development of computational methods and resources for quantitative LC/MS shotgun proteomics.
Relative quantitation of peptides and proteins across multiple samples is a fundamental technology for systems biology and biomarker discovery. Several methodologies have been developed including 2D-DIGE and isotope labelling for shotgun LC/MS proteomics. Our specific interest is in the development of computational methods and software for automating label-free LC/MS proteomics. We are also interested in developing repositories for peptide and protein quantitations that would enable global profiling of protein expression across cell-types, tissues and organisms.