Center for Proteomics and Bioinformatics

Modern applications of proteomics techniques followed by bioinformatics analyses put the Center for Proteomics and Bioinformatics at the forefront of translational research in the Case Western Reserve University School of Medicine.

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News and Announcements

School of Medicine researchers discover new target for personalized cancer therapy

A common cancer pathway causing tumor growth is being targeted by a number of new cancer drugs and shows promising results. A team of researchers at Case Western Reserve University School of Medicine has developed a novel method to disrupt this growth-signaling pathway, with findings that suggest a new treatment for breast, colon, melanoma and other cancers. Learn more>>

Time.com discusses proteomics and Big Data in Blood Work.

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Fortune magazine - Big Data

Classes - and even degree programs - focused on data analytics are cropping up all over the U.S. Read more at Fortune >>






Structural Biology and Biophysics Training Program

Structural Biology and Biophysics Training Program (SBB_TP)

The Structural Biology and Biophysics Training Program emphasizes quantitative methods and equips students to study cell and protein structure and function using state-of-the-art instrumentation and computing. The Department hosts outstanding research programs in the areas of structural biology and cellular ion channels and transporters.

Qualified students receive full tuition waiver, a stipend, and health benefits during the full duration of their studies.

Students can enter this training program by admission to the Interdepartmental Structural Biology and Biophysics Training Program (http://sbb-tp.case.edu).

Research Highlights

Visualizing the kinetic power stroke that drives proton-coupled zinc(ii) transport.

Visualizing the kinetic power stroke that drives proton-coupled zinc(ii) transport.

The proton gradient is a principal energy source for respiration-dependent active transport, but the structural mechanisms of proton-coupled transport processes are poorly understood. YiiP is a proton-coupled zinc transporter found in the cytoplasmic membrane of Escherichia coli. >>

Microbial and animal rhodopsins: structures, functions, and molecular mechanisms.

Microbial and animal rhodopsins: structures, functions, and molecular mechanisms.

Organisms of all domains of life use photoreceptor proteins to sense and respond to light. The light-sensitivity of photoreceptor proteins arises from bound chromophores such as retinal in retinylidene proteins, bilin in biliproteins, and flavin in flavoproteins. >>





Cross-talk between the ligand- and DNA-binding domains of estrogen receptor

Cross-talk between the ligand- and DNA-binding domains of estrogen receptor

Estrogen receptor alpha (ER.) is a hormone-responsive transcription factor that contains several discrete functional domains, including a ligand-binding domain (LBD) and a DNA-binding domain (DBD). Despite a wealth of knowledge about the behaviors of individual domains, the molecular mechanisms of cross-talk between LBD and DBD during signal transduction from hormone to DNA-binding of ERα remain elusive. >>

Seminars and Workshops

Research Highlights