Center for Proteomics and Bioinformatics

Modern applications of proteomics techniques followed by bioinformatics analyses put the Center for Proteomics and Bioinformatics at the forefront of translational research in the Case Western Reserve University School of Medicine.

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News and Announcements

Structural Biology and Biophysics Training Program (SBB_TP)

The Structural Biology and Biophysics Training Program emphasizes quantitative methods and equips students to study cell and protein structure and function using state-of-the-art instrumentation and computing. The Department hosts outstanding research programs in the areas of structural biology and cellular ion channels and transporters.

Qualified students receive full tuition waiver, a stipend, and health benefits during the full duration of their studies.

Students can enter this training program by admission to the Interdepartmental Structural Biology and Biophysics Training Program (http://sbb-tp.case.edu).

Summer 2012 Undergraduate Research Opportunities!

The Proteomics Research in Systems Medicine (PRISM) Program is looking for undergraduate students to work on 4 different research projects. These projects include:

  • Data analysis methods for finding informative subgroups of patients in high dimensional data.
  • Development of fluorescently labeled report viruses to study HIV entry dynamics.
  • Implement pathway scoring tools for disease classification.
  • Social Networks and Systems Analysis of Public Health.

Read more about the projects and how to apply.

Research Highlights

Beamline X3B: Characterization of metalloproteins by high-throughput X-ray absorption spectroscopy High-throughput X-ray absorption spectroscopy was used to measure transition metal content based on quantitative detection of X-ray fluorescence signals for 3879 purified proteins from several hundred different protein families generated by the New York SGX Research Center for Structural Genomics. Read more...

Systems biology analyses of gene expression and genome wide association study data in obstructive sleep apnea The precise molecular etiology of obstructive sleep apnea (OSA) is unknown; however recent research indicates that several interconnected aberrant pathways and molecular abnormalities are contributors to OSA. Identifying the genes and pathways associated with OSA can help to expand our understanding of the risk factors for the disease as well as provide new avenues for potential treatment. Read more...

Seminars and Workshops

  • 02/23/2012 - 12:00 - 1:00PM BRB 932 Systems Biology and Bioinformatics Journal Club - Giri Gokulrangan, Ph.D., a research associate at the CPB will be presenting "Driver mutations in histone H3.3 and chromatin remodeling genes in pediatric glioblastoma" (Schwartzenburger J, Korshunov A, Liu XY, et.al. Nature 2012 Jan 29;482(7384):226-31.doi:10.1038/nature 10833)

Research Highlights