Will integrate -omics data and enhance clinical and
translational research activities of CTSA investigators. The Translational Technologies Core of the CTSA, in the two
years of funding available so far, has been very successful in the
development and implementation of information technology systems to collect
and organize --omics data generated by various cores, through its Integrated
Multi-Modality Information Management System (MIMI). The next step is to
provide investigators with user-friendly tools to integrate this data with
biological and clinical information pertinent to their research goals.
Through collaborations between faculty in physiology, genetics,
bioinformatics, proteomics, biomedical engineering, and computer science we
will integrate --omics data in the context of, and driven by, the
topology of protein-protein interaction networks to provide a functional
framework for integrating different types of data. The resulting SMDA
tools for disease analysis will be web-based, open source, scalable, and
will ultimately serve clinical and translational researchers in Cleveland
in many areas of disease research, especially those that involve complex
phenotypes. It will be made available to the local community through
workshops and individual training of CTSA investigators and will be
disseminated to the wider CTSA community through the coordination and
outreach efforts of the national Translational Technologies Key Functions
Committee (TTKFC), of which, Dr. Chance, is a member.
Contacts:
Rod Nibbe, Ph.D. (rod.nibbe@case.edu)
Case Center for Proteomics and Bioinformatics
Case Western Reserve University
10900 Euclid Avenue
Cleveland, Ohio 44106
(phone) 216-368-1490
(fax) 216-368-6846