Systems Medicine Data Analysis

SMDA Pipeline

Technique: SMDA Pipeline

Will integrate -omics data and enhance clinical and translational research activities of CTSA investigators. The Translational Technologies Core of the CTSA, in the two years of funding available so far, has been very successful in the development and implementation of information technology systems to collect and organize --omics data generated by various cores, through its Integrated Multi-Modality Information Management System (MIMI). The next step is to provide investigators with user-friendly tools to integrate this data with biological and clinical information pertinent to their research goals. Through collaborations between faculty in physiology, genetics, bioinformatics, proteomics, biomedical engineering, and computer science we will integrate --omics data in the context of, and driven by, the topology of protein-protein interaction networks to provide a functional framework for integrating different types of data. The resulting SMDA tools for disease analysis will be web-based, open source, scalable, and will ultimately serve clinical and translational researchers in Cleveland in many areas of disease research, especially those that involve complex phenotypes. It will be made available to the local community through workshops and individual training of CTSA investigators and will be disseminated to the wider CTSA community through the coordination and outreach efforts of the national Translational Technologies Key Functions Committee (TTKFC), of which, Dr. Chance, is a member.

Rod Nibbe, Ph.D. (
Case Center for Proteomics and Bioinformatics
Case Western Reserve University
10900 Euclid Avenue
Cleveland, Ohio 44106
(phone) 216-368-1490
(fax) 216-368-6846